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Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate

Annals of the Rheumatic Diseases · 2008 · Vol. 68(6) · pp. 954–960

George A. Wells✉(University of Ottawa)J-C Becker(Bristol-Myers Squibb (United States))J. Teng(Bristol-Myers Squibb (Germany))Maxime Dougados(Assistance Publique – Hôpitaux de Paris)Michael Schiff(University of Colorado System)Josef S Smolen(Klinik Hietzing)Daniel Aletaha(Medical University of Vienna)Piet L. C. M. van Riel(Radboud University Medical Center)

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Abstract

The DAS28 (CRP) has been validated against radiographic progression and physical function. While the DAS28 (CRP) yielded a better EULAR response more often than the DAS28 (ESR), the validation profile was similar to the DAS28 (ESR), indicating that both measures are useful for assessing disease activity in patients with rheumatoid arthritis.

Rheumatoid Arthritis Research and Therapies Autoimmune and Inflammatory Disorders Research Musculoskeletal synovial abnormalities and treatmentsMedicineRheumatismErythrocyte sedimentation rateRheumatoid arthritisInternal medicineAbataceptPhysical therapyPlaceboC-reactive proteinRheumatology

MeSH terms

AbataceptAcute DiseaseAdultArthritis, RheumatoidArthrographyBlood SedimentationC-Reactive ProteinFemaleHumansMaleMiddle AgedSeverity of Illness IndexReproducibility of ResultsBiomarkersRandomized Controlled Trials as Topic