articleTop 1% cited
Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome
AIDS · 2010 · Vol. 24(15) · pp. 2381–2390
Graeme Meintjes✉(GTx (United States))Robert J. Wilkinson(Imperial College London)Chelsea Morroni(Western Cape Department of Health)Dominique J. Pepper(GF Jooste Hospital)Kevin Rebe(University of Cape Town)Molebogeng X. RangakaTolu Oni(Imperial College London)Gary Maartens(University of Cape Town)
Abstract
Prednisone reduced the need for hospitalization and therapeutic procedures and hastened improvements in symptoms, performance, and quality of life. It is important to investigate for drug-resistant tuberculosis and other causes for deterioration before administering glucocorticoids.
Infectious Diseases and TuberculosisPneumocystis jirovecii pneumonia detection and treatmentTuberculosis Research and EpidemiologyMedicinePrednisoneInterquartile rangePlaceboClinical endpointAdverse effectInternal medicineImmune reconstitution inflammatory syndromeRandomized controlled trialSurgery
MeSH terms
AdultDouble-Blind MethodGlucocorticoidsHumansMaleMiddle AgedPlacebosPrednisoneTuberculosisHIV InfectionsTreatment OutcomeCD4 Lymphocyte CountAntiretroviral Therapy, Highly ActiveImmune Reconstitution Inflammatory SyndromeYoung Adult
Funding
- Wellcome Trust
Citations
404
FWCI
33.81
field-weighted impact
References
36
Percentile
100%
vs. same field & year
Citations per year
Cited by
Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis
Clinical Infectious Diseases · 2016 · 1,426 citations
References
Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy
AIDS · 2005 · 633 citations
American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: Treatment of Tuberculosis
American Journal of Respiratory and Critical Care Medicine · 2003 · 1,948 citations
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