article Open AccessTop 1% cited
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
Gut · 2013 · Vol. 63(2) · pp. 281–291
Malin Johansson✉(University of Gothenburg)Jenny K. Gustafsson(University of Gothenburg)Jessica Holmén‐Larsson(University of Gothenburg)Karolina S. Jabbar(University of Gothenburg)Lijun Xia(Oklahoma Medical Research Foundation)Hua Xu(University of Arizona)Fayez K. Ghishan(University of Arizona)Frédéric A. Carvalho(Georgia State University)Andrew T. Gewirtz(Georgia State University)Henrik Sjövall(University of Gothenburg)Gunnar C. Hansson(University of Gothenburg)
Abstract
Normal human sigmoid colon has an inner mucus layer that is impenetrable to bacteria. The colon mucus in animal models that spontaneously develop colitis and in patients with active UC allows bacteria to penetrate and reach the epithelium. Thus colon mucus properties can be modulated, and this suggests a novel model of UC pathophysiology.
Inflammatory Bowel DiseaseGut microbiota and healthHelicobacter pylori-related gastroenterology studiesMucusMucinColitisUlcerative colitisEx vivoEpitheliumMucin 2PathologyBiologyMicrobiology
MeSH terms
AdolescentAdultAgedAnimalsColitisColitis, UlcerativeColonFemaleHumansIntestinal MucosaMaleMiddle AgedMucusIn Situ Hybridization, FluorescenceMice
Funding
- Swedish Cancer Foundation
- Stiftelsen för Strategisk Forskning
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- National Institutes of Health
- Sahlgrenska Akademin
Citations
995
FWCI
37.80
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
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References
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Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection
Gastroenterology · 2006 · 1,612 citations
Inflammatory bowel disease: Etiology and pathogenesis
Gastroenterology · 1998 · 2,074 citations
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
Infection and Immunity · 1998 · 1,472 citations
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