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Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood

Thorax · 2008 · Vol. 63(11) · pp. 974–980

A. John Henderson✉(University of Bristol)Raquel Granell(University of Bristol)Jon Heron(University of Bristol)Andrea Sherriff(University of Bristol)Angela Simpson(University of Manchester)Ashley Woodcock(University of Manchester)D. P. Strachan(St George's, University of London)Seif O. Shaheen(Imperial College London)Jonathan A C Sterne(University of Bristol)

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Abstract

The wheezing phenotypes most strongly associated with atopy and airway responsiveness were characterised by onset after age 18 months. This has potential implications for the timing of environmental influences on the initiation of atopic wheezing in early childhood.

Asthma and respiratory diseases Neonatal Respiratory Health Research Chronic Obstructive Pulmonary Disease (COPD) ResearchAtopyWheezeMedicineAsthmaRespiratory soundsAirwayPediatricsSpirometryImmunologySurgery

MeSH terms

AsthmaChildChild, PreschoolFemaleForced Expiratory VolumeHumansHypersensitivity, ImmediateInfantMalePeak Expiratory Flow RatePhenotypePregnancyPregnancy ComplicationsRespiratory SoundsBronchial Hyperreactivity