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C−C Bond Formation via Double C−H Functionalization: Aerobic Oxidative Coupling as a Method for Synthesizing Heterocoupled Biaryls
Organic Letters · 2007 · Vol. 9(16) · pp. 3137–3139
Timothy A. Dwight✉(University of Rhode Island)Nicholas R. Rue(University of Rhode Island)Dagmara Charyk(University of Rhode Island)Ryan Josselyn(University of Rhode Island)Brenton DeBoef(University of Rhode Island)
Abstract
The aerobic oxidative coupling of arenes such as benzofuran and N-substituted indoles with benzene and derivatives thereof is described. The reaction is shown to take place in both inter- and intramolecular scenarios.
Catalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsAlkaloids: synthesis and pharmacologyChemistryIntramolecular forceBenzofuranSurface modificationOxidative coupling of methaneOxidative phosphorylationBenzeneCoupling (piping)Combinatorial chemistryCoupling reaction
MeSH terms
BenzofuransHeterocyclic CompoundsIndolesOxidation-ReductionMolecular StructureCombinatorial Chemistry Techniques
Funding
- National Institutes of Health
Citations
474
FWCI
25.81
field-weighted impact
References
19
Percentile
100%
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