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A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Cell Metabolism · 2009 · Vol. 9(4) · pp. 311–326

Christopher B. Newgard✉(Duke University)Jie An(Duke University)James R. Bain(Duke University)Michael J. Muehlbauer(Duke University)Robert Stevens(Duke University)Lillian F. Lien(Duke University)Andrea M. Haqq(Duke University)Svati H. Shah(Duke Medical Center)Michelle Arlotto(Duke University)Cris A. Slentz(Duke Medical Center)James Rochon(Duke University)Dianne Gallup(Duke University)Olga Ilkayeva(Duke University)Brett R. Wenner(Duke University)William S. Yancy(Duke Medical Center)Howard Eisenson(Duke Medical Center)Gerald Musante(Duke Medical Center)Richard S. Surwit(Duke Medical Center)David S. Millington(Duke University)Mark D. Butler(Duke University)Laura P. Svetkey(Duke University)

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Metabolomics and Mass Spectrometry Studies Adipose Tissue and Metabolism Diet and metabolism studiesInsulin resistanceEndocrinologyInternal medicineCatabolismMetaboliteInsulinBranched-chain amino acidBiologyPI3K/AKT/mTOR pathwayAmino acid

MeSH terms

Amino Acids, Branched-ChainAnimalsDemographyDietary FatsFeeding BehaviorFemaleHormonesHumansInsulinInsulin ResistanceMaleMiddle AgedObesityMass SpectrometryThinness

Funding

National Institutes of Health

Citations

3,105

FWCI

36.84

field-weighted impact

References

Percentile

100%

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Citations per year

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References

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Cell Metabolism · 2008 · 1,952 citations

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