articleTop 10% cited

Catalyzed Propargylic Substitution

European Journal of Organic Chemistry · 2009 · Vol. 2009(36) · pp. 6263–6276

Remko J. Detz✉(University of Amsterdam)Henk Hiemstra(University of Amsterdam)Jan H. van Maarseveen(University of Amsterdam)

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Abstract

Abstract Besides being a versatile entity for further chemical transformations, the propargylic subunit is also part of various natural products, fine chemicals, and synthetic pharmaceuticals. Propargylic substitution reactions, however, are rather unexplored. An overview of this emerging field is presented. We especially focus on experimental results that deal with catalyzed substitutions of propargylic alcohols and their derivatives. Finally, some enantioselective propargylic substitution methods are discussed.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

Catalytic Alkyne Reactions Synthetic Organic Chemistry Methods Asymmetric Synthesis and CatalysisChemistrySubstitution (logic)Enantioselective synthesisCombinatorial chemistrySubstitution reactionOrganic chemistryCatalysisStereochemistryComputer scienceProgramming language

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Direct Nucleophilic S<sub>N</sub>1‐Type Reactions of Alcohols

European Journal of Organic Chemistry · 2010 · 321 citations

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