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Detecting Subsecond Dopamine Release with Fast-Scan Cyclic Voltammetry in Vivo

Clinical Chemistry · 2003 · Vol. 49(10) · pp. 1763–1773

Donita L. Robinson(Center for Neurosciences)B. Jill Venton(Center for Neurosciences)Michael L. Heien(Center for Neurosciences)R. Mark Wightman✉(University of North Carolina at Chapel Hill)

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Abstract

Fast-scan cyclic voltammetry offers real-time measurements of changes in extracellular dopamine concentrations in vivo. With its subsecond time resolution, micrometer-dimension spatial resolution, and chemical selectivity, it is the most suitable technique currently available to measure transient concentration changes of dopamine.

Neuroscience and Neuropharmacology Research Neurotransmitter Receptor Influence on Behavior Electrochemical Analysis and ApplicationsDopamineCyclic voltammetryIn vivoVoltammetryChemistryNeuroscienceBiophysicsElectrodeBiologyElectrochemistry