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Evidence for a Locus Regulating Total Serum IgE Levels Mapping to Chromosome 5
Genomics · 1994 · Vol. 23(2) · pp. 464–470
Deborah A. Meyers✉(Johns Hopkins University)Dirkje S. Postma(Johns Hopkins University)Carolien Panhuysen(Johns Hopkins University)Jianfeng Xu(Beatrix Kinderziekenhuis)Pamela J. Amelung(Johns Hopkins University)Roy C. Levitt(Johns Hopkins University)ER Bleecker(Beatrix Kinderziekenhuis)
Abstract
Genetics studies of total serum IgE levels were performed since high IgE levels correlate with clinical expression of allergy and asthma. Families ascertained through a parent with asthma were genotyped for markers on 5q where there are multiple candidate genes that may influence the control of IgE and inflammation. Evidence for linkage of the IgE phenotype to 5q was obtained by both sib-pair and lod score analysis with evidence for recessive inheritance of high IgE levels from segregation analysis. These findings represent a major step in mapping genes important in the regulation of allergic responses and the pathogenesis of asthma.
Asthma and respiratory diseasesMonoclonal and Polyclonal Antibodies ResearchT-cell and B-cell ImmunologyBiologyImmunoglobulin EPathogenesisLocus (genetics)ImmunologyGenetic linkagePhenotypeGeneticsCandidate geneAllergy
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Allergic Rhinitis and Its Impact on Asthma
Journal of Allergy and Clinical Immunology · 2001 · 3,543 citations
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