article Open AccessTop 1% cited
Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register
Journal of Neurology Neurosurgery & Psychiatry · 2005 · Vol. 77(2) · pp. 193–198
James Morrow✉(University of Ulster)
Abstract
Only 4.2% of live births to women with epilepsy had an MCM. The MCM rate for polytherapy exposure was greater than for monotherapy exposure. Polytherapy regimens containing valproate had significantly more MCMs than those not containing valproate. For monotherapy exposures, carbamazepine was associated with the lowest risk of MCM.
Pharmacological Effects and Toxicity StudiesPregnancy and Medication ImpactEpilepsy research and treatmentLamotrigineCarbamazepineEpilepsyMedicinePregnancyOdds ratioProspective cohort studyConfidence intervalObstetricsPediatrics
MeSH terms
AnticonvulsantsDose-Response Relationship, DrugDrug Therapy, CombinationEpilepsyFemaleFollow-Up StudiesGestational AgeHumansInfant, NewbornPregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesRegistriesRisk
Funding
- Pfizer
- Sanofi
- Epilepsy Action
- Epilepsiatutkimussäätiö
- Cilag
Citations
877
FWCI
82.75
field-weighted impact
References
46
Percentile
100%
vs. same field & year
Citations per year
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References
Probable Inference, the Law of Succession, and Statistical Inference
Journal of the American Statistical Association · 1927 · 3,590 citations
Descriptive Epidemiology of Epilepsy: Contributions of Population-Based Studies From Rochester, Minnesota
Mayo Clinic Proceedings · 1996 · 698 citations
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