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Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index

Journal of Clinical Oncology · 2013 · Vol. 31(12) · pp. 1539–1547

Lisa Martin✉(University of New Brunswick)Laura Birdsell(University of New Brunswick)Neil Macdonald(University of New Brunswick)Tony Reiman(University of New Brunswick)M. Thomas Clandinin(University of New Brunswick)Linda J. McCargar(University of New Brunswick)Rachel A. Murphy(University of New Brunswick)Sunita Ghosh(University of New Brunswick)Michael B. Sawyer(University of New Brunswick)Vickie E. Baracos(University of New Brunswick)

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Abstract

CT images reveal otherwise occult muscle depletion. Patients with cancer who are cachexic by the conventional criterion (involuntary weight loss) and by two additional criteria (muscle depletion and low muscle attenuation) share a poor prognosis, regardless of overall body weight.

Nutrition and Health in Aging Frailty in Older Adults Cancer survivorship and careMedicineUnderweightBody mass indexOverweightObesity paradoxCachexiaWeight lossInternal medicineCancerObesity

MeSH terms

AdultAge FactorsAgedBody CompositionCachexiaCanadaCancer Care FacilitiesFemaleFollow-Up StudiesGastrointestinal NeoplasmsHumansLung NeoplasmsMaleMiddle AgedNeoplasm Staging

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