review Open AccessTop 10% cited
Effects of Intensive Blood Pressure Lowering on Cardiovascular and Renal Outcomes: A Systematic Review and Meta-Analysis
PLoS Medicine · 2012 · Vol. 9(8) · pp. e1001293–e1001293
Jicheng Lv(The University of Sydney)Bruce Neal(The University of Sydney)Parya Ehteshami(The University of Sydney)Toshiharu Ninomiya(The University of Sydney)Mark Woodward(The University of Sydney)Anthony Rodgers(The University of Sydney)Haiyan Wang(The University of Sydney)Stephen MacMahon(The University of Sydney)Fiona Turnbull(The University of Sydney)Graham S. Hillis(The University of Sydney)John Chalmers(The University of Sydney)Vlado Perkovic✉(The University of Sydney)
Abstract
Intensive BP lowering regimens provided greater vascular protection than standard regimens that was proportional to the achieved difference in systolic BP, but did not have any clear impact on the risk of death or serious adverse events. Further trials are required to more clearly define the risks and benefits of BP targets below those currently recommended, given the benefits suggested by the currently available data.
Blood Pressure and Hypertension StudiesCardiovascular Health and Disease PreventionCardiovascular Syncope and Autonomic DisordersMedicineBlood pressureStroke (engine)Myocardial infarctionInternal medicineMeta-analysisIntensive careRelative riskAlbuminuriaPlacebo
MeSH terms
Antihypertensive AgentsBlood PressureCardiovascular DiseasesCardiovascular SystemClinical Trials as TopicHumansKidneyKidney DiseasesRegression AnalysisRisk FactorsTreatment Outcome
Funding
- Amgen
- Pfizer
- Servier
- Medical Research Council
- National Health and Medical Research Council
Citations
778
FWCI
6.83
field-weighted impact
References
81
Percentile
98%
vs. same field & year
Citations per year
Cited by
2018 ESC/ESH Guidelines for the management of arterial hypertension
European Heart Journal · 2018 · 10,258 citations
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Circulation · 2019 · 4,494 citations
2018 ESC/ESH Guidelines for the management of arterial hypertension
Journal of Hypertension · 2018 · 2,790 citations
KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease
Kidney International · 2021 · 1,336 citations
2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD
European Heart Journal · 2019 · 4,808 citations
Drinking Water Nitrate and Human Health: An Updated Review
International Journal of Environmental Research and Public Health · 2018 · 1,426 citations
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Hypertension · 2017 · 7,315 citations
Heart Disease and Stroke Statistics—2021 Update
Circulation · 2021 · 5,571 citations
References
2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension
Journal of Hypertension · 2003 · 2,689 citations
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
The Lancet · 2002 · 10,173 citations
Blood pressure and cardiovascular disease in the Asia Pacific region
Journal of Hypertension · 2003 · 637 citations
2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension
Journal of Hypertension · 2007 · 1,838 citations
Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study
Journal of Hypertension · 2009 · 351 citations
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Annals of Internal Medicine · 2009 · 10,387 citations
Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes
Kidney International · 2002 · 849 citations
Combination Therapy Versus Monotherapy in Reducing Blood Pressure: Meta-analysis on 11,000 Participants from 42 Trials
The American Journal of Medicine · 2009 · 920 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.