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Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

Immunity · 1999 · Vol. 10(1) · pp. 105–115

Robyn Catlett-Falcone(University of South Florida)Terry H. Landowski(Moffitt Cancer Center)Marc M. Oshiro(Florida College)James Turkson(Moffitt Cancer Center)Alexander Levitzki(Hebrew University of Jerusalem)Rocco Savino(Istituto di Genetica Molecolare)Gennaro Ciliberto(Istituto di Genetica Molecolare)Lynn C. Moscinski(Florida College)José L. Fernández-Luna(Marqués de Valdecilla University Hospital)Gabriel Núñez(University of Michigan–Ann Arbor)William S. Dalton(Florida College)Richard Jove✉(Florida College)

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Cytokine Signaling Pathways and Interactions Medicinal Plant Pharmacodynamics Research Multiple Myeloma Research and TreatmentsBiologyApoptosisMultiple myelomaCancer researchSTAT3Signal transductionBone marrowInterleukin 6Cell biologyCytokine

MeSH terms

AnimalsAntineoplastic AgentsDNA-Binding ProteinsGene Expression RegulationHumansImmunity, InnateMultiple MyelomaPromoter Regions, GeneticProtein-Tyrosine KinasesTranscription, GeneticTransfectionTumor Cells, CulturedSignal TransductionTrans-Activators3T3 Cells

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STAT3 Target Genes Relevant to Human Cancers