articleTop 10% cited

Persistent immune activation in HIV-1 infection is associated with progression to AIDS

AIDS · 2003 · Vol. 17(13) · pp. 1881–1888

Mette D. Hazenberg✉(Sanquin)Sigrid A. Otto(Karl Landsteiner Society)Birgit HB van BenthemMarijke Roos(Karl Landsteiner Society)Roel A. CoutinhoJoep MA Lange(University of Amsterdam)Dörte Hamann(Karl Landsteiner Society)Maria PrinsFrank Miedema(University of Amsterdam)

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Abstract

Increased T cell activation has predictive value for HIV-1 disease progression even before seroconversion. These data support the hypothesis that persistent hyperactivation of the immune system may lead to erosion of the naive T cell pool and CD4 T cell depletion.

HIV Research and Treatment Immune Cell Function and Interaction HIV/AIDS Research and InterventionsImmunologyHuman immunodeficiency virus (HIV)ImmunopathologyImmune systemMedicineVirologyViral diseaseSidaLentivirus

MeSH terms

Acquired Immunodeficiency SyndromeCell DivisionFollow-Up StudiesHIV SeropositivityHumansLymphocyte ActivationPrognosisProspective StudiesRNA, ViralCD4-Positive T-LymphocytesHIV-1HIV InfectionsCD8-Positive T-LymphocytesDisease ProgressionCD4 Lymphocyte Count

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Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections