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Psychobiological Mechanisms of Resilience and Vulnerability: Implications for Successful Adaptation to Extreme Stress

American Journal of Psychiatry · 2004 · Vol. 161(2) · pp. 195–216
Dennis S. Charney

Abstract

The opportunity now exists to bring to bear the full power of advances in our understanding of the neurobiological basis of behavior to facilitate the discoveries needed to predict, prevent, and treat stress-related psychopathology.

Stress Responses and CortisolChild and Adolescent Psychosocial and Emotional DevelopmentResilience and Mental HealthPsychologyNeurochemicalVulnerability (computing)PsychopathologyPsychological resilienceClinical psychologyDevelopmental psychologyNeuroscienceSocial psychology

MeSH terms

Adaptation, PsychologicalAnimalsBrainConditioning, PsychologicalCorticotropin-Releasing HormoneDopamineEstrogensExtinction, PsychologicalFearHumansHydrocortisoneLocus CoeruleusNeuropeptide YNorepinephrineReceptors, GABA-A
Citations
1,604
FWCI
21.56
field-weighted impact
References
227
Percentile
100%
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Citations per year
References
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Archives of Internal Medicine · 1997 · 1,340 citations
Neurobiology of Depression
Neuron · 2002 · 3,159 citations
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