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Final report of the Medical Research Council/Royal College of Obstetricians and Gynaecologists Multicentre Randomised Trial of Cervical Cerclage

BJOG An International Journal of Obstetrics & Gynaecology · 1993 · Vol. 100(6) · pp. 516–523

MRC/RCOG Working Party on Cervical Cerclage✉M. C. MacnaughtonIain ChalmersVictor DubowitzP M DunnAdrian GrantKlim McPhersonJames F. PearsonR PetoA. C. Turnbull

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Abstract

These results suggest that the operation had an important beneficial effect in 1 in 25 cases in the trial (95% confidence interval (CI) 1 in 12 to 1 in 300 sutures). Its use is associated with increased medical intervention and puerperal pyrexia. Nevertheless, this trial suggests that, on balance, cervical cerclage should be offered to women at high risk, such as those with a history of three or more pregnancies ending before 37 weeks gestation.

Preterm Birth and Chorioamnionitis Pregnancy-related medical research Pelvic floor disorders treatmentsMedicineCervical cerclageMiscarriageObstetricsCervical insufficiencyPregnancyRandomized controlled trialGynecologyGestationSurgery

MeSH terms

Abortion, SpontaneousAdultBirth WeightUterine Cervical IncompetenceCervix UteriFemaleGestational AgeHospitalizationHumansObstetric Labor, PrematurePregnancyPregnancy OutcomeRisk FactorsSuturesTime Factors