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Aminoglycosides: Activity and Resistance
Antimicrobial Agents and Chemotherapy · 1999 · Vol. 43(4) · pp. 727–737
Marie‐Paule Mingeot‐Leclercq✉(UCLouvain)Y. Glupczynski✉(CHU Dinant Godinne UCL Namur)Paul M. Tulkens✉(UCLouvain)
Abstract
Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of life-threatening infections ([28][1]). Their history begins in 1944 with streptomycin and was thereafter marked by the successive introduction of a series of milestone compounds (
Antibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in BacteriaAntimicrobial Peptides and ActivitiesStreptomycinMilestoneAntibioticsBroad spectrumBiologyMedicineMicrobiologyIntensive care medicineChemistryHistory
MeSH terms
AcetyltransferasesAminoglycosidesAnti-Bacterial AgentsBacteriaDrug Resistance, MicrobialHumansPhosphotransferasesDrug Design
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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C
Biochemistry · 1984 · 2,703 citations
Clinical Response to Aminoglycoside Therapy: Importance of the Ratio of Peak Concentration to Minimal Inhibitory Concentration
The Journal of Infectious Diseases · 1987 · 1,131 citations
Aminoglycosides: Nephrotoxicity
Antimicrobial Agents and Chemotherapy · 1999 · 743 citations
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