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Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action

Journal of Pharmacology and Experimental Therapeutics · 2007 · Vol. 321(3) · pp. 892–901
Neuroinflammation and Neurodegeneration MechanismsHistone Deacetylase Inhibitors ResearchAlzheimer's disease research and treatmentsNeuroprotectionNeuroinflammationTrichostatin APharmacologyHistone deacetylaseIschemiaMicrogliaSodium butyrateMedicineBrain ischemia

MeSH terms

AnimalsAnti-Inflammatory AgentsBrainButyratesCerebral InfarctionBrain IschemiaDisease Models, AnimalEnzyme InhibitorsHistonesHydroxamic AcidsMaleValproic AcidTumor Suppressor Protein p53Rats, Sprague-DawleyMicroglia

Funding

  • National Institutes of Health
  • National Institute of Mental Health
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