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A Fast and Flexible Statistical Model for Large-Scale Population Genotype Data: Applications to Inferring Missing Genotypes and Haplotypic Phase

The American Journal of Human Genetics · 2006 · Vol. 78(4) · pp. 629–644
Paul ScheetMatthew Stephens
Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsGenetic and phenotypic traits in livestockLinkage disequilibriumInternational HapMap ProjectHaplotypePopulationMissing dataCluster analysisStatistical modelStatisticsExpectation–maximization algorithmGenotype

MeSH terms

CalibrationGenetics, PopulationGenotypeHaplotypesHumansProbabilityModels, Statistical

Funding

  • National Institutes of Health
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References
The Combination of Forecasts
Journal of the Operational Research Society · 1969 · 3,091 citations
Accounting for Decay of Linkage Disequilibrium in Haplotype Inference and Missing-Data Imputation
The American Journal of Human Genetics · 2005 · 1,359 citations
Maximum Likelihood from Incomplete Data Via the <i>EM</i> Algorithm
Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1977 · 49,286 citations
A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data
The American Journal of Human Genetics · 2003 · 3,521 citations
A New Statistical Method for Haplotype Reconstruction from Population Data
The American Journal of Human Genetics · 2001 · 7,519 citations
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