articleTop 1% cited
A Graphene Platform for Sensing Biomolecules
Angewandte Chemie International Edition · 2009 · Vol. 48(26) · pp. 4785–4787
Chunhua Lü(Fuzhou University)Huanghao Yang✉(First Institute of Oceanography)Zhu Chun-ling(First Institute of Oceanography)Xi Chen(Fuzhou University)Guonan Chen(Fuzhou University)
Abstract
Sensitive platform: The use of graphene oxide (GO) as a platform for the sensitive and selective detection of DNA and proteins is presented. The interaction of GO and dye-labeled single-stranded DNA leads to quenching of the dye fluorescence. Conversely, the presence of a target DNA or protein leads to the binding of the dye-labeled DNA and target, releasing the DNA from GO, thereby restoring the dye fluorescence (see picture).
Advanced biosensing and bioanalysis techniquesGraphene and Nanomaterials ApplicationsCarbon and Quantum Dots ApplicationsGrapheneBiomoleculeDNAFluorescenceQuenching (fluorescence)NanotechnologyOxideChemistryBiophysicsMaterials science
MeSH terms
CarbonDNA, Single-StrandedFluorescent DyesProteinsSpectrometry, FluorescenceBiosensing TechniquesAptamers, Nucleotide
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