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Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcome

BMC Cancer · 2013 · Vol. 13(1) · pp. 1–1

Emman Shubbar✉(University of Gothenburg)Anikó Kovács(Sahlgrenska University Hospital)Shahin Hajizadeh(Sahlgrenska University Hospital)Toshima Z. Parris(Sahlgrenska University Hospital)Szilárd Nemes(University of Gothenburg)K. Gunnarsdóttir(Sahlgrenska University Hospital)Zakaria Einbeigi(Sahlgrenska University Hospital)Per Karlsson(University of Gothenburg)Khalil Helou(Sahlgrenska University Hospital)

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Abstract

These findings suggest that cytoplasmic CCNB2 may function as an oncogene and could serve as a potential biomarker of unfavorable prognosis over short-term follow-up in breast cancer.

Cancer-related Molecular Pathways Gene expression and cancer classification Molecular Biology Techniques and ApplicationsBreast cancerOncologyProportional hazards modelTissue microarrayImmunohistochemistryMedicineInternal medicineCancerSurgical oncologyHazard ratio

MeSH terms

AdultAgedBreast NeoplasmsFemaleHumansImmunohistochemistryMiddle AgedPrognosisTime FactorsBiomarkers, TumorUp-RegulationMultivariate AnalysisChi-Square DistributionProportional Hazards ModelsIn Situ Hybridization, Fluorescence