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Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility.

Heart · 1995 · Vol. 74(3) · pp. 247–253

Keld E. Sørensen✉(SickKids Foundation)David S. Celermajer(Great Ormond Street Hospital)D. J. Spiegelhalter(SickKids Foundation)Dimitri Georgakopoulos(Hospital for Sick Children)J. Robinson(Hospital for Sick Children)O Thomas(SickKids Foundation)John Deanfield(University College London)

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Abstract

Vascular responses to endothelium dependent and independent stimuli in systemic arteries can be studied non-invasively in man. Subjects should be studied on at least two occasions before and after any intervention, to optimise the chance of showing a significant effect from any potentially beneficial therapy.

Cardiovascular Health and Disease Prevention Cerebrovascular and Carotid Artery Diseases Blood Pressure and Hypertension StudiesMedicineBrachial arteryReproducibilityCoefficient of variationAnalysis of varianceImaging phantomCardiologyUltrasoundRepeated measures designBlood flow

MeSH terms

AdultAnalysis of VarianceArteriesArteriosclerosisEndothelium, VascularFemaleHumansMaleMiddle AgedModels, StructuralRegional Blood FlowSensitivity and SpecificityUltrasonographyReproducibility of Results

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697

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Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery