articleTop 1% cited
The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) and its relationship to fertilization and embryo development
Human Reproduction · 2002 · Vol. 17(4) · pp. 990–998
Ian D. Morris✉(University of Manchester)
Abstract
This study contributes to the evidence of DNA damage within sperm. High loads of DNA damage measured by the Comet assay were predictive of failure of embryo development after ICSI. As it is likely that sperm with DNA damage contributed to successful fertilization and in-vitro development, potential adverse effects remain to be clarified.
Sperm and Testicular FunctionReproductive Biology and FertilityReproductive Health and TechnologiesComet assaySpermDNA damageAndrologyHuman fertilizationBiologySemenEmbryoDNA fragmentationFertilisation
MeSH terms
AdultAgingCleavage Stage, OvumDNA DamageFertilizationEmbryonic and Fetal DevelopmentHumansMaleMiddle AgedPredictive Value of TestsSperm CountSperm MotilitySpermatozoaMultivariate AnalysisComet Assay
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References
Sperm chromatin damage impairs human fertility
Fertility and Sterility · 2000 · 715 citations
Relative Impact of Oxidative Stress on the Functional Competence and Genomic Integrity of Human Spermatozoa1
Biology of Reproduction · 1998 · 788 citations
Detection of Deoxyribonucleic Acid Fragmentation in Human Sperm: Correlation with Fertilization in Vitro1
Biology of Reproduction · 1997 · 757 citations
Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic
Human Reproduction · 1999 · 1,114 citations
Oxidative stress, DNA damage and the Y chromosome
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