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Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

Nature Medicine · 2008 · Vol. 15(1) · pp. 42–49
Krisztián NémethAsada LeelahavanichkulPeter S.T. YuenBalázs MayerAlissa ParmeleeKent DoiPamela Gehron RobeyKantima LeelahavanichkulBeverly H. KollerJared M. BrownXuzhen HuIvett JelinekRobert A. StarÉva Mezey
Mesenchymal stem cell researchNeonatal Respiratory Health ResearchTissue Engineering and Regenerative MedicineMesenchymal stem cellStromal cellTumor necrosis factor alphaImmunologyImmune systemBone marrowSepsisReprogrammingCancer researchProstaglandin E2 receptor

MeSH terms

AnimalsBone Marrow CellsCecal DiseasesCecumHumansMacrophagesMaleMice, Inbred BALB CMice, Inbred C57BLModels, BiologicalTransplantationWounds, PenetratingDinoprostoneSurvival AnalysisBone Marrow Transplantation

Funding

  • National Institutes of Health
  • National Cancer Institute
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Dental and Craniofacial Research
Citations
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