article Open AccessTop 1% cited
Breast tumor copy number aberration phenotypes and genomic instability
BMC Cancer · 2006 · Vol. 6(1) · pp. 96–96
Jane Fridlyand✉(University of California, San Francisco)Antoine M. Snijders(UCSF Helen Diller Family Comprehensive Cancer Center)Bauke Ylstra(University of California, San Francisco)Hua Li(Cancer Research Institute)Adam B. Olshen(UCSF Helen Diller Family Comprehensive Cancer Center)Richard Segraves(University of California, San Francisco)Shanaz H. Dairkee(UCSF Helen Diller Family Comprehensive Cancer Center)Taku A. Tokuyasu(UCSF Helen Diller Family Comprehensive Cancer Center)Britt‐Marie Ljung(UCSF Helen Diller Family Comprehensive Cancer Center)Ajay N. Jain(UCSF Helen Diller Family Comprehensive Cancer Center)Jane McLennan(UCSF Helen Diller Family Comprehensive Cancer Center)John L. Ziegler(UCSF Helen Diller Family Comprehensive Cancer Center)Koei Chin(UCSF Helen Diller Family Comprehensive Cancer Center)Sandy DeVries(University of California, San Francisco)Heidi S. Feiler(Lawrence Berkeley National Laboratory)Joe W. Gray(UCSF Helen Diller Family Comprehensive Cancer Center)Frederic M. Waldman(UCSF Helen Diller Family Comprehensive Cancer Center)Daniel Pinkel(University of California, San Francisco)Donna G. Albertson(University of California, San Francisco)
Abstract
Many of the genes associated with higher frequency of copy number aberrations are direct targets of E2F, supporting the hypothesis that deregulation of the Rb pathway is a major contributor to chromosomal instability in breast tumors. These observations are consistent with failure to find mutations in sporadic tumors in genes that have roles in maintenance or manipulation of the genome.
Genomic variations and chromosomal abnormalitiesCancer Genomics and DiagnosticsDNA Repair MechanismsGenome instabilityChromosome instabilityBiologyComparative genomic hybridizationTelomereCopy-number variationGeneticsPhenotypeGeneDNA repair
MeSH terms
AdultAgedBreast NeoplasmsChromosome AberrationsChromosomes, HumanDNA, NeoplasmFemaleHumansKaryotypingMiddle AgedNeoplasm ProteinsNucleic Acid HybridizationPhenotypeSignal TransductionGene Expression Regulation, Neoplastic
Funding
- U.S. Department of Energy
- Avon Foundation for Women
- National Institutes of Health
- University of California, San Francisco
Citations
294
FWCI
22.50
field-weighted impact
References
48
Percentile
100%
vs. same field & year
Citations per year
Cited by
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival
Breast Cancer Research and Treatment · 2011 · 905 citations
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
Cancer Cell · 2006 · 1,315 citations
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Cancer Cell · 2006 · 3,214 citations
References
High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
Nature Genetics · 1998 · 2,247 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.