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Metabolism of nicotine to cotinine studied by a dual stable isotope method
Clinical Pharmacology & Therapeutics · 1994 · Vol. 56(5) · pp. 483–493
Neal L. Benowitz✉(University of California, San Francisco)Peyton Jacob(San Francisco General Hospital)
Abstract
Our study provides quantitative data on individual variability in the extent of C-oxidation of nicotine to cotinine and a quantitative perspective on the use of plasma cotinine as an indicator of daily intake of nicotine from tobacco.
Synthesis and Biological EvaluationSmoking Behavior and CessationNicotinic Acetylcholine Receptors StudyCotinineNicotineChemistryPharmacologyMedicineChromatographyInternal medicine
MeSH terms
AdultCotinineDeuteriumFemaleHumansMaleMiddle AgedNicotineOxidation-ReductionSmoking
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499
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