reviewTop 10% cited
Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs
European Journal of Medicinal Chemistry · 2003 · Vol. 38(7-8) · pp. 645–659
Caroline Charlier✉(University of Namur)Catherine Michaux(University of Namur)
Inflammatory mediators and NSAID effectsSynthesis and biological activitySynthesis and Reactions of Organic CompoundsCyclooxygenaseChemistryArachidonate 5-lipoxygenaseLipoxygenaseAnti-inflammatoryPharmacologyDual (grammatical number)Dual roleEnzymeBiochemistry
MeSH terms
AnimalsAnti-Inflammatory Agents, Non-SteroidalArachidonate 5-LipoxygenaseBinding SitesCell MembraneHumansInflammationIsoenzymesMembrane ProteinsModels, MolecularProstaglandin-Endoperoxide SynthasesPyrazolesStructure-Activity RelationshipLipoxygenase InhibitorsCyclooxygenase Inhibitors
Citations
427
FWCI
6.53
field-weighted impact
References
134
Percentile
97%
vs. same field & year
Citations per year
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References
Cyclooxygenase 2: a molecular target for cancer prevention and treatment
Trends in Pharmacological Sciences · 2003 · 650 citations
Cyclooxygenase inhibitors – current status and future prospects
European Journal of Medicinal Chemistry · 2001 · 658 citations
Cyclooxygenases: Structural, Cellular, and Molecular Biology
Annual Review of Biochemistry · 2000 · 2,902 citations
Cyclooxygenase in biology and disease
The FASEB Journal · 1998 · 2,501 citations
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
Journal of Biological Chemistry · 1996 · 1,987 citations
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