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IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
Journal of Allergy and Clinical Immunology · 2001 · Vol. 108(3) · pp. 430–438
Sophie Molet✉(Cegep de Sainte Foy)Qutayba Hamid(McGill University)Francis Davoineb(Cegep de Sainte Foy)Esra Nutku(McGill University)Rame Tahaa(Cegep de Sainte Foy)Nathalie Pagé(Cegep de Sainte Foy)Ron Olivenstein(Cegep de Sainte Foy)Jack A. Elias(Cegep de Sainte Foy)Jamila Chakir(Cegep de Sainte Foy)
Abstract
Our results, which demonstrate for the first time that eosinophils are a potential source of IL-17 within asthmatic airways, suggest that IL-17 might have the potential to amplify inflammatory responses through the release of proinflammatory mediators such as alpha-chemokines.
Asthma and respiratory diseasesPediatric health and respiratory diseasesIL-33, ST2, and ILC PathwaysBronchoalveolar lavageCytokineImmunocytochemistryImmunologyMedicineSputumChemokineEosinophilInterleukin 8Peripheral blood mononuclear cell
MeSH terms
AdultAsthmaBronchiBronchoalveolar Lavage FluidChemotactic FactorsEosinophilsFemaleFibroblastsGrowth SubstancesHumansMaleSputumInterleukin-6CytokinesInterleukin-8
Funding
- Canadian Thoracic Society
- Canadian Lung Association
- Medical Research Council Canada
- Medical Research Council
Citations
945
FWCI
7.82
field-weighted impact
References
39
Percentile
98%
vs. same field & year
Citations per year
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References
Human IL-17: a novel cytokine derived from T cells
The Journal of Immunology · 1995 · 1,020 citations
Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes
Journal of Investigative Dermatology · 1998 · 564 citations
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.
The Journal of Experimental Medicine · 1996 · 1,507 citations
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