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Persistent Escalation of Alcohol Drinking in C57BL/6J Mice With Intermittent Access to 20% Ethanol
Alcoholism Clinical and Experimental Research · 2011 · Vol. 35(11) · pp. 1938–1947
Lara S. Hwa✉(Tufts University)Adam Chu(Tufts University)Sally A. Levinson(Tufts University)Tala M. Kayyali(Tufts University)Joseph F. DeBold(Tufts University)Klaus A. Miczek(Tufts University)
Abstract
The IA method in B6 mice is advantageous because it induces escalated, voluntary, and preferential per os ethanol intake, behavior that may mimic a cardinal feature of human alcohol dependence, though the exact nature and site of ethanol acting in the brain and blood as a result of IA has yet to be determined.
Neurotransmitter Receptor Influence on BehaviorAdipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsEthanolAlcoholPsychologyAcamprosatePsychiatryMedicineInternal medicineChemistryNaltrexoneBiochemistry
MeSH terms
Alcohol DrinkingEthanolAlcoholismAnimalsDisease Models, AnimalDrinking BehaviorFemaleFood PreferencesMaleMice, Inbred C57BLSeverity of Illness IndexAlcohol Withdrawal SeizuresMice
Funding
- National Institutes of Health
Citations
362
FWCI
4.64
field-weighted impact
References
85
Percentile
96%
vs. same field & year
Citations per year
References
Intermittent Access to 20% Ethanol Induces High Ethanol Consumption in Long–Evans and Wistar Rats
Alcoholism Clinical and Experimental Research · 2008 · 621 citations
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Alcoholism Clinical and Experimental Research · 2002 · 390 citations
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