articleTop 10% cited

Sex hormones, inflammation and the metabolic syndrome: a population-based study

European Journal of Endocrinology · 2003 · Vol. 149(6) · pp. 601–608

DE Laaksonen(Kuopio University Hospital)Leo Niskanen(Kuopio University Hospital)Kari Punnonen(Kuopio University Hospital)K. Nyyssönen(University of Eastern Finland)TP Tuomainen(University of Eastern Finland)Riitta Salonen(University of Eastern Finland)Rainer Rauramaa(Kuopio University Hospital)J T Salonen✉(University of Eastern Finland)

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Abstract

Low testosterone and SHBG levels were strongly associated not only with components of the metabolic syndrome, but also with the metabolic syndrome itself, independently of body mass index. Furthermore, sex hormones were associated with inflammation and body iron stores. Even in the absence of late-stage consequences such as diabetes and cardiovascular disease, subtle derangements in sex hormones are present in the metabolic syndrome, and may contribute to its pathogenesis.

Hormonal and reproductive studies Pharmacology and Obesity Treatment Sexual Differentiation and DisordersSex hormone-binding globulinMetabolic syndromeInternal medicineEndocrinologyBody mass indexTestosterone (patch)MedicinePopulationDiabetes mellitusHormone

MeSH terms

FinlandHumansInflammationMaleMiddle AgedSex Hormone-Binding GlobulinTestosteroneCohort StudiesBody Mass IndexDehydroepiandrosterone SulfateMetabolic SyndromeSerum

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442

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6.08

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