reviewTop 1% cited
The Neural Basis of Addiction: A Pathology of Motivation and Choice
American Journal of Psychiatry · 2005 · Vol. 162(8) · pp. 1403–1413
Peter W. Kalivas✉(Medical University of South Carolina)Nora D. Volkow(National Institute on Drug Abuse)
Abstract
Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatergic drive in response to drug-associated stimuli.
Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchGlutamatergicNucleus accumbensNeuroscienceAddictionPrefrontal cortexPsychologyAnterior cingulate cortexDopamineExcitatory postsynaptic potentialNeuroplasticity
MeSH terms
AnimalsBrainChoice BehaviorDopamineGlobus PallidusHumansModels, NeurologicalMotivationNeural PathwaysNucleus AccumbensRecurrenceRodentiaBehavior, AddictivePrefrontal CortexSubstance-Related Disorders
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