article Open AccessTop 1% cited
Characterization of human plasma-derived exosomal RNAs by deep sequencing
BMC Genomics · 2013 · Vol. 14(1) · pp. 319–319
Xiaoyi Huang✉(Medical College of Wisconsin)Tiezheng Yuan(Medical College of Wisconsin)Michael Tschannen(Medical College of Wisconsin)Zhifu Sun(Mayo Clinic)Howard J. Jacob(Medical College of Wisconsin)Meijun Du(Medical College of Wisconsin)Meihua Liang(Harbin Medical University)Rachel L. Dittmar(Medical College of Wisconsin)Yong Liu(Medical College of Wisconsin)Mingyu Liang(Harbin Medical University)Manish Kohli(Mayo Clinic)Stephen N. Thibodeau(Mayo Clinic in Arizona)Lisa A. Boardman(Mayo Clinic in Arizona)Liang Wang(Medical College of Wisconsin)
Abstract
This study demonstrated that a wide variety of RNA species are embedded in the circulating vesicles. To our knowledge, this is the first report that applied deep sequencing to discover and characterize profiles of plasma-derived exosomal RNAs. Further characterization of these extracellular RNAs in diverse human populations will provide reference profiles and open new doors for the development of blood-based biomarkers for human diseases.
Extracellular vesicles in diseaseCancer-related molecular mechanisms researchMicroRNA in disease regulationRNABiologySmall RNAmicroRNASmall nuclear RNADeep sequencingNon-coding RNARibosomal RNAIntronPiwi-interacting RNA
MeSH terms
Base SequenceBlood DonorsChromosome MappingExtracellular SpaceHumansPlasmaSequence Analysis, RNARNA StabilityMicroRNAsExosomesHigh-Throughput Nucleotide SequencingTranscriptome
Funding
- Mayo Clinic
- Medical College of Wisconsin
- National Institutes of Health
Citations
1,061
FWCI
27.66
field-weighted impact
References
71
Percentile
100%
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Citations per year
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