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Cholesterol-Dependent Cytolysins, a Family of Versatile Pore-Forming Toxins
Infection and Immunity · 2005 · Vol. 73(10) · pp. 6199–6209
Rodney K. Tweten✉(University of Oklahoma Health Sciences Center)
Abstract
The cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins that are produced by more than 20 species from the genera Clostridium , Streptococcus , Listeria , Bacillus , and Arcanobacterium . The pore-forming mechanism of these toxins exhibits two hallmark characteristics:
Clostridium difficile and Clostridium perfringens researchStreptococcal Infections and TreatmentsToxin Mechanisms and ImmunotoxinsBiologyComputational biologyMicrobiology
MeSH terms
BacteriaBacterial ToxinsCell MembraneCholesterolCytotoxinsProtein ConformationProtein Transport
Funding
- National Institutes of Health
Citations
463
FWCI
7.34
field-weighted impact
References
104
Percentile
98%
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Citations per year
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References
In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2
Infection and Immunity · 1987 · 722 citations
PEST sequences and regulation by proteolysis
Trends in Biochemical Sciences · 1996 · 1,628 citations
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