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Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

PLoS Medicine · 2007 · Vol. 4(3) · pp. e76–e76

Anthony E. Civitarese✉(Pennington Biomedical Research Center)Stacy Carling(Pennington Biomedical Research Center)Leonie K. Heilbronn(Pennington Biomedical Research Center)Mathew H Hulver(Pennington Biomedical Research Center)Barbara Ukropcová(Pennington Biomedical Research Center)Walter Deutsch(Pennington Biomedical Research Center)Steven R. Smith(Pennington Biomedical Research Center)Éric Ravussin(Pennington Biomedical Research Center)

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Abstract

The observed increase in muscle mitochondrial DNA in association with a decrease in whole body oxygen consumption and DNA damage suggests that caloric restriction improves mitochondrial function in young non-obese adults.

Adipose Tissue and Metabolism Mitochondrial Function and Pathology Genetics, Aging, and Longevity in Model OrganismsTFAMCalorie restrictionMitochondrial biogenesisCitric acid cycleBiologyCitrate synthaseInternal medicineMitochondrial DNAEndocrinologyMitochondrion

MeSH terms

AdultDNA DamageEnergy MetabolismFemaleHumansMaleMiddle AgedMitochondria, MuscleNitric OxideExerciseOxidative StressMuscle, SkeletalGene Expression ProfilingCaloric RestrictionSirtuins

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