article Open AccessTop 1% cited
Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate
Human Reproduction · 2003 · Vol. 18(7) · pp. 1383–1394
Jane S. Fisher✉(University of Edinburgh)
Abstract
Abnormal development of Sertoli cells, leading to abnormalities in other cell types, is our hypothesized explanation for the abnormal changes in DBP-exposed animals. As the testicular and other changes in DBP-exposed rats have all been reported in human TDS, DBP exposure in utero may provide a useful model for defining the cellular pathways in TDS.
Effects and risks of endocrine disrupting chemicalsSexual Differentiation and DisordersSperm and Testicular FunctionDibutyl phthalateIn uteroDysgenesisPhthalateMedicineAndrologyToxicologyBiologyPregnancyChemistry
MeSH terms
Age FactorsAnimalsBody WeightDibutyl PhthalateDisease Models, AnimalFemaleHumansHyperplasiaLeydig CellsMaleOrgan SizePregnancyPrenatal Exposure Delayed EffectsSeminiferous TubulesSertoli Cells
Funding
- European Commission
Citations
541
FWCI
17.72
field-weighted impact
References
58
Percentile
100%
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Citations per year
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Desert hedgehog (Dhh) Gene Is Required in the Mouse Testis for Formation of Adult-Type Leydig Cells and Normal Development of Peritubular Cells and Seminiferous Tubules
Biology of Reproduction · 2000 · 438 citations
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