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PhosphinooxazolinesA New Class of Versatile, Modular P,N<i>-</i>Ligands for Asymmetric Catalysis
Accounts of Chemical Research · 2000 · Vol. 33(6) · pp. 336–345
Günter Helmchen✉(University of Basel)Andreas Pfaltz(University of Basel)
Abstract
Chiral phosphinooxazolines (PHOX ligands), which coordinate to a metal center with a N- and a P-atom, allow effective enantiocontrol in a variety of metal-catalyzed reactions. They are readily synthesized, and because of their modular structure, the steric and electronic properties can be tailored for a specific application by variation of the oxazoline ring, the backbone, and the phosphine moiety.
Asymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisSynthesis and Catalytic ReactionsMoietySteric effectsOxazolineChemistryRing (chemistry)Modular designPhosphineCombinatorial chemistryCatalysisStereochemistry
MeSH terms
CatalysisLigandsMolecular ConformationOrganometallic CompoundsOrganophosphorus CompoundsOxazolesPalladiumPhosphinesRubidiumStereoisomerism
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References
The chemistry of 2-oxazolines (1985–present)
Tetrahedron · 1994 · 564 citations
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