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Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Study

Journal of Clinical Oncology · 2000 · Vol. 18(17) · pp. 3068–3077

Hans von der Maase✉(Aarhus University Hospital)Steen Werner Hansen(Aarhus University Hospital)J.T. Roberts(Aarhus University Hospital)Luigi Dogliotti(Aarhus University Hospital)T. Oliver(Aarhus University Hospital)Malcolm J. Moore(Aarhus University Hospital)I. Bodrogi(Aarhus University Hospital)Peter Albers(Aarhus University Hospital)Alexander Knuth(Aarhus University Hospital)Christian Lippert(Aarhus University Hospital)Pierre Kerbrat(Aarhus University Hospital)Pedro Sánchez‐Rovira(Aarhus University Hospital)Peter Wersäll(Aarhus University Hospital)Simon Cleall(Aarhus University Hospital)D. Roychowdhury(Aarhus University Hospital)Irene Tomlin(Aarhus University Hospital)Carla Visseren‐Grul(Aarhus University Hospital)Pierfranco Conté(Aarhus University Hospital)

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Abstract

GC provides a similar survival advantage to MVAC with a better safety profile and tolerability. This better-risk benefit ratio should change the standard of care for patients with locally advanced and metastatic TCC from MVAC to GC.

Bladder and Urothelial Cancer Treatments Colorectal Cancer Treatments and Studies Gastric Cancer Management and OutcomesMedicineCisplatinGemcitabineVinblastineDoxorubicinBladder cancerOncologyMethotrexateChemotherapyInternal medicine

MeSH terms

GemcitabineAnti-Infective AgentsAntineoplastic Combined Chemotherapy ProtocolsUrinary Bladder NeoplasmsCarcinoma, Transitional CellCisplatinDeoxycytidineDoxorubicinFemaleHospitalizationHumansMaleMethotrexateMiddle AgedNeoplasm Metastasis

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Guideline for the Management of Nonmuscle Invasive Bladder Cancer (Stages Ta, T1, and Tis): 2007 Update