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Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions

Journal of Bone and Joint Surgery · 2001 · Vol. 83(Pt 2) · pp. S1–151

Gary E. Friedlaender✉Clayton R. Perry(Yale University)J. Dean Cole(Yale University)Stephen D. Cook(Yale University)G Cierný(Yale University)George F. Muschler(Yale University)Gregory A. Zych(Yale University)Jason H. Calhoun(Yale University)Amy J. LaForte(Yale University)Samuel Yin(Yale University)

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Abstract

rhOP-1 (BMP-7), implanted with a type I collagen carrier, was a safe and effective treatment for tibial nonunions. This molecule provided clinical and radiographic results comparable with those achieved with bone autograft, without donor site morbidity.

Bone fractures and treatments Orthopaedic implants and arthroplasty Bone Tissue Engineering MaterialsMedicineNonunionIntramedullary rodBone morphogenetic proteinSurgeryBone healingInvestigational device exemptionBone morphogenetic protein 2Clinical trialTibia

MeSH terms

AdultCollagenDrug CarriersFemaleFracture Fixation, IntramedullaryFractures, UnunitedHumansMaleProspective StudiesRadiographyRecombinant ProteinsTibial FracturesBone TransplantationTransforming Growth Factor betaDrug Delivery Systems

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Autologous bone graft vs synthetic bone graft in treatment of non-union in long bones