article Open AccessTop 1% cited
Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly
Lara D. Veeken · 2010 · Vol. 50(1) · pp. 124–131
James Galloway✉Kimme L Hyrich(Versus Arthritis)Louise Mercer(Versus Arthritis)William G Dixon(Versus Arthritis)Bo Fu(Versus Arthritis)Andrew Ustianowski(North Manchester General Hospital)Kath Watson(Versus Arthritis)Mark Lunt(Versus Arthritis)Deborah Symmons(University of Manchester)on behalf of the British Society for Rheumatology Biologics Register
Abstract
These data add to currently available evidence suggesting that anti-TNF therapy is associated with a small but significant overall risk of SI. This must be balanced against the risks associated with poor disease control or alternative treatments.
Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders ResearchSystemic Lupus Erythematosus ResearchMedicineEtanerceptAdalimumabInfliximabInternal medicineRheumatoid arthritisHazard ratioRheumatologyCohortOdds ratio
MeSH terms
Tumor Necrosis Factor InhibitorsAgedAntibodies, MonoclonalArthritis, RheumatoidFemaleUnited KingdomHumansInfectionsMaleMiddle AgedRegistriesRegression AnalysisRisk FactorsAntirheumatic AgentsTumor Necrosis Factors
Citations
665
FWCI
31.04
field-weighted impact
References
34
Percentile
100%
vs. same field & year
Citations per year
Cited by
The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment
Lara D. Veeken · 2012 · 531 citations
References
Frequency of infection in patients with rheumatoid arthritis compared with controls: A population‐based study
Arthritis & Rheumatism · 2002 · 1,225 citations
Signalling pathways of the TNF superfamily: a double-edged sword
Nature reviews. Immunology · 2003 · 2,747 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.