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NF- B activation and overexpression of regulated genes in human diabetic nephropathy

Nephrology Dialysis Transplantation · 2004 · Vol. 19(10) · pp. 2505–2512

Sergio Mezzano✉(Austral University of Chile)C. ArosAlejandra DroguettM. Eugenia BurgosLeopoldo ArdilesClaudio FloresH. SchneiderMarta Ruiz‐OrtegaJ. Egido

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Abstract

The activation of NF-kappaB and the transcription of certain pro-inflammatory chemokines in tubular epithelial cells are markers of progressive DN. Proteinuria might be one of the main factors inducing the observed pro-inflammatory phenotype.

NF-κB Signaling Pathways Immune Response and Inflammation Advanced Glycation End Products researchChemokineIn situ hybridizationDiabetic nephropathyNephropathyMonocyteMedicineImmunohistochemistryInflammationDownregulation and upregulationNF-κB

MeSH terms

AdultDiabetes Mellitus, Type 2Diabetic NephropathiesFemaleGene Expression RegulationHumansImmunohistochemistryInflammationKidneyMaleMiddle AgedRNA, MessengerBiomarkersUp-RegulationGene Expression

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Inflammatory Targets in Diabetic Nephropathy