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Sustained Efficacy of Eszopiclone Over 6 Months of Nightly Treatment: Results of a Randomized, Double-Blind, Placebo-Controlled Study in Adults with Chronic Insomnia
SLEEP · 2003 · Vol. 26(7) · pp. 793–799
Andrew D. Krystal✉(Duke University Hospital)James K. Walsh(St. Vincent's Medical Center)Eugene Laska(New York University)Judy Caron(Sunovion (United States))David A. Amato(Sunovion (United States))Thomas Wessel(Sunovion (United States))Thomas Roth
Abstract
Throughout 6 months, eszopiclone improved all of the components of insomnia as defined by DSM-IV, including patient ratings of daytime function. This placebo-controlled study of eszopiclone provides compelling evidence that long-term pharmacologic treatment of insomnia is efficacious.
Sleep and related disordersSleep and Wakefulness ResearchYouth Substance Use and School AttendanceSleep onsetAlertnessPlaceboInsomniaSleep onset latencyMedicinePsychologyPrimary InsomniaSleep diarySomnolence
MeSH terms
AdultAgedChronic DiseaseCircadian RhythmDouble-Blind MethodFemaleHumansHypnotics and SedativesSleep Initiation and Maintenance DisordersMaleMiddle AgedPiperazinesTime FactorsWakefulnessAzabicyclo Compounds
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Recommendations for a Standard Research Assessment of Insomnia
SLEEP · 2006 · 1,198 citations
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