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High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients

Nephrology Dialysis Transplantation · 2009 · Vol. 24(9) · pp. 2792–2796

Guillaume Jean✉(Association pour l'Utilisation du Rein Artificiel)J.-C. Terrat(Association pour l'Utilisation du Rein Artificiel)Thierry Vanel(Association pour l'Utilisation du Rein Artificiel)J.M. Hurot(Association pour l'Utilisation du Rein Artificiel)Christie Lorriaux(Association pour l'Utilisation du Rein Artificiel)Brice Mayor(Association pour l'Utilisation du Rein Artificiel)C. Chazot(Association pour l'Utilisation du Rein Artificiel)

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Abstract

This study demonstrated a high level of circulating FGF-23 in LHD patients, despite infrequent hyperphosphataemia. However, phosphataemia is still the main factor correlating with serum FGF-23. The association of higher serum FGF-23 levels with mortality and VC, regardless of the serum phosphate levels, has thus been confirmed.

Parathyroid Disorders and Treatments Pancreatitis Pathology and Treatment Dialysis and Renal Disease ManagementMedicineFibroblast growth factor 23Fibroblast growth factorHemodialysisInternal medicineFibroblastEndocrinologyFGF21BiochemistryIn vitro

MeSH terms

Fibroblast Growth Factor-23AgedAged, 80 and overFemaleFibroblast Growth FactorsFranceRenal DialysisHumansKidney Failure, ChronicMaleMiddle AgedProspective StudiesRisk FactorsTime FactorsMultivariate Analysis

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PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop

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FGF23 induces left ventricular hypertrophy

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References

Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease

Journal of the American Society of Nephrology · 2005 · 912 citations

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