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MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

Cardiovascular Research · 2009 · Vol. 82(1) · pp. 21–29

Sashwati Roy✉(The Ohio State University Wexner Medical Center)Savita Khanna(The Ohio State University Wexner Medical Center)Syed-Rehan A. Hussain(The Ohio State University Wexner Medical Center)Sabyasachi Biswas(The Ohio State University Wexner Medical Center)Ali Azad(The Ohio State University Wexner Medical Center)Cameron Rink(The Ohio State University Wexner Medical Center)Surya Gnyawali(The Ohio State University Wexner Medical Center)Shani Shilo(The Ohio State University Wexner Medical Center)Gerard J. Nuovo(The Ohio State University)Chandan K. Sen(The Ohio State University Wexner Medical Center)

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Abstract

This work constitutes the first report describing changes in miR expression in response to IR in the mouse heart, showing that miR-21 regulates MMP-2 expression in CFs of the infarct zone via a PTEN pathway.

MicroRNA in disease regulation Cancer-related molecular mechanisms research Circular RNAs in diseasesTensinPTENmicroRNAGene silencingBiologyGene expressionGene expression profilingIn situ hybridizationRegulation of gene expressionMolecular biology

MeSH terms

AnimalsCells, CulturedDisease Models, AnimalFibroblastsImmunohistochemistryMaleMice, Inbred C57BLMyocardial InfarctionRNA, MessengerTime FactorsMyocardial Reperfusion InjuryGene Expression Regulation, EnzymologicCluster AnalysisPolymerase Chain ReactionIn Situ Hybridization

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611

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19.63

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