articleTop 10% cited
trans-Activation of PPARα and PPARγ by Structurally Diverse Environmental Chemicals
Toxicology and Applied Pharmacology · 1999 · Vol. 161(2) · pp. 209–218
Erin K. MaloneyDavid J. Waxman✉(Boston University)
Peroxisome Proliferator-Activated ReceptorsMetabolism, Diabetes, and CancerAdipose Tissue and MetabolismPerfluorooctanoic acidPhthalatePeroxisome proliferator-activated receptor alphaPeroxisomePeroxisome proliferator-activated receptorNuclear receptorMetaboliteChemistryPeroxisome proliferatorReceptor
MeSH terms
AnimalsDiethylhexyl PhthalateEnvironmental PollutantsHerbicidesHumans2-Methyl-4-chlorophenoxyacetic AcidPlasmidsSpecies SpecificityTetrachloroethyleneTranscription FactorsTransfectionTrichloroethylene2,4-Dichlorophenoxyacetic AcidTranscriptional ActivationTrans-Activators
Funding
- U.S. Environmental Protection Agency
- Boston University
- National Institutes of Health
- National Institute of Environmental Health Sciences
Citations
376
FWCI
3.05
field-weighted impact
References
77
Percentile
92%
vs. same field & year
Citations per year
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References
P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR
Archives of Biochemistry and Biophysics · 1999 · 762 citations
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Journal of Biological Chemistry · 1995 · 3,617 citations
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
Molecular and Cellular Biology · 1995 · 1,646 citations
Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643
Carcinogenesis · 1997 · 486 citations
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