articleTop 1% cited
Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis
Organic Letters · 2004 · Vol. 6(17) · pp. 2853–2855
Timothy R. Chan✉(Scripps Research Institute)Robert Hilgraf(Scripps Research Institute)K. Barry Sharpless(Scripps Research Institute)Valery V. Fokin(Scripps Research Institute)
Abstract
Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.
Click Chemistry and ApplicationsChemical Synthesis and AnalysisAdvanced biosensing and bioanalysis techniquesChemistryDisproportionationCopperCatalysisCombinatorial chemistryLigand (biochemistry)LigationDerivative (finance)Polymer chemistryOrganic chemistry
MeSH terms
AminesCatalysisCopperLigandsOxidation-ReductionPolymersTriazolesMolecular Structure
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References
Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides
The Journal of Organic Chemistry · 2002 · 8,416 citations
A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines
Tetrahedron Letters · 1975 · 5,105 citations
Asymmetric catalytic cyclopropanation of olefins: bis-oxazoline copper complexes
Tetrahedron Letters · 1990 · 524 citations
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
Angewandte Chemie International Edition · 2002 · 11,380 citations
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