articleTop 1% cited

Inflammation after trauma: Microglial activation and traumatic brain injury

Annals of Neurology · 2011 · Vol. 70(3) · pp. 374–383

Anil Ramlackhansingh(Hammersmith Hospital)David J. Brooks(Hammersmith Hospital)Richard Greenwood(University College London)Subrata K. Bose(Hammersmith Hospital)Federico Turkheimer(Imperial College London)Kirsi M. Kinnunen(Goldsmiths University of London)Steve Gentleman(Hammersmith Hospital)Rolf A. Heckemann(Hammersmith Hospital)Karen Gunanayagam(Imperial College London)Giorgio Gelosa(Imperial College London)David Sharp✉(Imperial College London)

View via DOI Publisher page

Abstract

We demonstrate that increased microglial activation can be present up to 17 years after TBI. This suggests that TBI triggers a chronic inflammatory response particularly in subcortical regions. This highlights the importance of considering the response to TBI as evolving over time and suggests interventions may be beneficial for longer intervals after trauma than previously assumed.

Traumatic Brain Injury and Neurovascular Disturbances S100 Proteins and Annexins Advanced Neuroimaging Techniques and ApplicationsTraumatic brain injuryMedicineMicrogliaMagnetic resonance imagingNeuroscienceChronic traumatic encephalopathyNeuroinflammationPutamenInflammationDiffusion MRI

MeSH terms

AdultAmnesiaBrain InjuriesCognition DisordersEducational StatusFemaleHumansImage Processing, Computer-AssistedInflammationIsoquinolinesMacrophage ActivationMagnetic Resonance ImagingMaleMemoryMiddle Aged