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The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis

Nephrology Dialysis Transplantation · 2010 · Vol. 26(4) · pp. 1327–1339

Paolo Raggi✉(Emory University)Glenn M. Chertow(Stanford University)P. U. TorresBotond Csiky(University of Pecs)A Naso(University of Padua)K. NossuliM. MoustafaWilliam G. Goodman(Amgen (United States))N. Lopez(Amgen (United States))Gerry Downey(Amgen (United States))Bastian Dehmel(Amgen (Switzerland))Jürgen Floege(RWTH Aachen University)on behalf of the ADVANCE Study Group

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Abstract

In hemodialysis patients with moderate to severe secondary hyperparathyroidism, cinacalcet plus low-dose vitamin D sterols may attenuate vascular and cardiac valve calcification.

Parathyroid Disorders and Treatments Vitamin D Research Studies Thyroid and Parathyroid SurgeryCinacalcetMedicineSecondary hyperparathyroidismVitamin D and neurologyParicalcitolHemodialysisCalcitriolHyperparathyroidismInternal medicineAgatston score

MeSH terms

CinacalcetAdultCalcinosisCoronary Artery DiseaseDose-Response Relationship, DrugFemaleFollow-Up StudiesRenal DialysisHumansHyperparathyroidism, SecondaryKidney Failure, ChronicMaleMiddle AgedNaphthalenesPrognosis

Citations

553

FWCI

21.56

field-weighted impact

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100%

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Cited by

A current understanding of vascular calcification in CKD