article

Anti-AIDS Agents. 48. Anti-HIV Activity of Moronic Acid Derivatives and the New Melliferone-Related Triterpenoid Isolated from Brazilian Propolis

Journal of Natural Products · 2001 · Vol. 64(10) · pp. 1278–1281

Junko Itô✉(Universidade Estadual de Campinas (UNICAMP))Fang‐Rong Chang(Universidade Estadual de Campinas (UNICAMP))Hui‐Kang Wang(Universidade Estadual de Campinas (UNICAMP))Yong Kun Park(Universidade Estadual de Campinas (UNICAMP))Masaharu Ikegaki(Universidade Estadual de Campinas (UNICAMP))Nicole Kilgore(Universidade Estadual de Campinas (UNICAMP))Kuo‐Hsiung Lee(Universidade Estadual de Campinas (UNICAMP))

View via DOI Publisher page

Abstract

A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (2) showed significant anti-HIV activity (EC(50) <0.1 microg/mL, TI >186) and was modified to develop more potent anti-AIDS agents.

Natural product bioactivities and synthesis Bee Products Chemical Analysis Phytochemical compounds biological activitiesPropolisTriterpenoidTriterpenePharmacognosyTraditional medicineHuman immunodeficiency virus (HIV)Biological activityChemistryStereochemistryTerpenoid

MeSH terms

BrazilCells, CulturedDrug Evaluation, PreclinicalEnzyme-Linked Immunosorbent AssayHumansLymphocytesMagnetic Resonance SpectroscopyOleanolic AcidPlants, MedicinalPropolisStructure-Activity RelationshipTriterpenesZidovudineMolecular StructureHIV-1

Citations

259

FWCI

1.27

field-weighted impact

References

Percentile

79%

vs. same field & year

Citations per year

Cited by

Recent Advances in the Chemical Composition of Propolis