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R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation

Journal of Pharmacology and Experimental Therapeutics · 2006 · Vol. 319(3) · pp. 998–1008

Sylvia Braselmann✉(King's College London)Vanessa Taylor(Guy's Hospital)H. Zhao(Guy's Hospital)Su Wang(Rigel (United States))Catherine Sylvain(King's College London)Muhammad Baluom(Guy's Hospital)Kunbin Qu(Guy's Hospital)Ellen Herlaar(King's College London)Angela Lau(King's College London)Chi Young(King's College London)Brian Wong(Rigel (United States))Scott Lovell(Guy's Hospital)Thomas Sun(Guy's Hospital)Gary Park(Guy's Hospital)Ankush Argade(King's College London)Stipo Jurčević(Rigel (United States))Polly Pine(Guy's Hospital)Rajinder Singh(King's College London)Elliott B. Grossbard(Rigel (United States))Donald G. Payan(King's College London)Esteban S. Masuda(Rigel (United States))

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Mast cells and histamine Monoclonal and Polyclonal Antibodies Research Coagulation, Bradykinin, Polyphosphates, and AngioedemaSykDegranulationChemistrySignal transductionLYNFc receptorCell biologyImmune systemInflammationMast cell

MeSH terms

AnimalsAntigen-Antibody ComplexArthritis, ExperimentalArthus ReactionB-LymphocytesBasophilsCells, CulturedCrystallographyDouble-Blind MethodEnzyme InhibitorsHumansImmunoglobulin GInflammationLipopolysaccharidesMacrophages

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509

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