articleTop 10% cited
β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease
Archives of Neurology · 2002 · Vol. 59(9) · pp. 1381–1381
Hiroaki Fukumoto✉(Massachusetts General Hospital)
Abstract
The BACE protein and activity levels are increased in brain regions affected by amyloid deposition and remain increased despite significant neuronal and synaptic loss in AD.
Alzheimer's disease research and treatmentsAmyloidosis: Diagnosis, Treatment, OutcomesParkinson's Disease Mechanisms and TreatmentsNeocortexAmyloid precursor proteinChemistryAlzheimer's diseaseCerebellar cortexTemporal cortexNeuroscienceBiochemistryCerebellumEndocrinology
MeSH terms
AgedAlzheimer DiseaseAmyloidCerebellar CortexEnzyme-Linked Immunosorbent AssayFemaleHumansImmunohistochemistryMaleEndopeptidasesPrecipitin TestsGene Expression Regulation, EnzymologicAmyloid beta-PeptidesAspartic Acid EndopeptidasesSynaptophysin
Funding
- Massachusetts General Hospital
- National Institutes of Health
Citations
706
FWCI
10.46
field-weighted impact
References
63
Percentile
99%
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Citations per year
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